No available data support the potential response of relapsed recurrent renal cell carcinoma (RCC) patients treated with systemic targeted therapies (TT) after completion of adjuvant sunitinib. In this study, we aimed to assess the efficacy and tolerability of rechallenge with sunitinib and other TT in advanced setting.
In this multi-institutional retrospective study, relapsed RCC patients were re-challenged with sunitinib or other systemic TT as first-line therapeutic approach after failed sunitinib adjuvant treatment. Patient characteristics, treatments and clinical outcomes were recorded. The primary end point was progression-free survival (PFS). Secondary end points were objective response rate (ORR) and overall survival (OS).
34 relapses were recorded, 25 patients (73.5%) were male. 25 patients were treated with systemic TT: 65% of patients received TT against Vascular Endothelial Growth Factor pathway (VEGF-TT, including sunitinib), 21.7% received mTOR inhibitors and 13%, immunotherapy. Median time to relapse was 20.3 months (IQR 5.2-20.4) from diagnosis, and 7.5 months (IQR 1.0-8.5) from adjuvant suntinib (AS) ending. At a median follow-up of 23.5 months, 24/25 patients had progressed on first-line systemic therapy. Median PFS was 12.0 months (95% CI: 5.78-18.2). There were no statistical differences in PFS between different treatments or sunitinib rechallenge. PFS was not statistically different in patients relapsing on or after AS (≤ 6 or > 6 months after AS ending). ORR was 20.5%. Median OS was 29.1 months (95% CI: 16.4-41.8).
Rechallenge with sunitinib or other systemic therapies is still a feasible therapeutic option that provides advanced or metastastic RCC patients with additional clinical benefits on PFS and OS after failed response to adjuvant sunitinib.
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2021.
All research outputs
#4,164,963
of 34,378,656 outputs
Outputs from British Journal of Urology
#1,357
of 7,944 outputs
Outputs of similar age
#76,950
of 480,228 outputs
Outputs of similar age from British Journal of Urology
#29
of 66 outputs
Altmetric has tracked 34,378,656 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,944 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 480,228 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
