Title |
The effect of pheniramine on fentanyl-induced cough: a randomized, double blinded, placebo controlled clinical study
|
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Published in |
Brazilian Journal of Anesthesiology (English edition), July 2016
|
DOI | 10.1016/j.bjane.2014.11.018 |
Pubmed ID | |
Authors |
Zakir Arslan, Eyup Serhat Çalık, Bekir Kaplan, Elif Oral Ahiskalioglu |
Abstract |
There are many studies conducted on reducing the frequency and severity of fentayl-induced cough during anesthesia induction. We propose that pheniramine maleate, an antihistaminic, may suppress this cough. We aim to observe the effect of pheniramine on fentanyl-induced cough during anesthesia induction. This is a double-blinded, prospective, three-arm parallel, randomized clinical trial of 120 patients with ASA (American Society of Anesthesiologists) physical status III and IV who aged ≥18 and scheduled for elective open heart surgery during general anesthesia. Patients were randomly assigned to three groups of 40 patients, using computer-generated random numbers: placebo group, pheniramine group, and lidocaine group. Cough incidence differed significantly between groups. In the placebo group, 37.5% of patients had cough, whereas the frequency was significantly decreased in pheniramine group (5%) and lidocaine group (15%) (Fischer exact test, p=0.0007 and p=0.0188, respectively). There was no significant change in cough incidence between pheniramine group (5%) and lidocaine group (15%) (Fischer exact test, p=0.4325). Cough severity did also change between groups. Post Hoc tests with Bonferroni showed that mean cough severity in placebo differed significantly than that of pheniramine group and lidocaine group (p<0.0001 and p=0.009, respectively). There was no significant change in cough severity between pheniramine group and lidocaine group (p=0.856). Intravenous pheniramine is as effective as lidocaine in preventing fentayl-induced cough. Our results emphasize that pheniramine is a convenient drug to decrease this cough. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 19% |
Professor | 2 | 10% |
Researcher | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 10 | 48% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 38% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Social Sciences | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unknown | 10 | 48% |