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The effects of memantine on recovery, cognitive functions, and pain after propofol anesthesia

Overview of attention for article published in Brazilian Journal of Anesthesiology (English edition), September 2016
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Title
The effects of memantine on recovery, cognitive functions, and pain after propofol anesthesia
Published in
Brazilian Journal of Anesthesiology (English edition), September 2016
DOI 10.1016/j.bjane.2015.03.002
Pubmed ID
Authors

Ulku Emik, Yusuf Unal, Mustafa Arslan, Cengiz Bekir Demirel

Abstract

Postoperative cognitive dysfunction refers to the problems associated with thought and memory that are often experienced after major surgery. The aim of this study is to evaluate the effects of intraperitoneally administered memantine on recovery, cognitive functions, and pain after propofol anesthesia. The study was conducted in Gazi University Animal Research Laboratory, Ankara, Turkey in January 2012. Twenty-four adult female Wistar Albino rats weighing 170-270g were educated for 300s in the radial arm maze (RAM) over three days. Group P was administered 150mgkg(-1) of intraperitoneal (IP) propofol; Group M was given 1mgkg(-1) of IP memantine; and Group MP was given 1mgkg(-1) of IP memantine before being administered 150mgkg(-1) of IP propofol. The control group received only IP saline. RAM and hot plate values were obtained after recovery from the groups that received propofol anesthesia and 30min after the administration of drugs in other two groups. The duration of recovery for Group MP was significantly shorter than Group P (p<0.001), and the number of entries and exits in the RAM by Group MP was significantly higher during the first hour when compared to Group P (p<0.0001). Hot plate values, on the other hand, were found to be significantly increased in all groups when compared to the control values, aside from Group C (p<0.0001). In this study, memantine provided shorter recovery times, better cognitive functions, and reduced postoperative pain. From this study, we find that memantine has beneficial effects on recovery, cognitive functions, and pain after propofol anesthesia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 24%
Researcher 3 14%
Student > Master 3 14%
Other 2 10%
Student > Doctoral Student 1 5%
Other 3 14%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 9 43%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Nursing and Health Professions 2 10%
Mathematics 1 5%
Other 2 10%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2018.
All research outputs
#17,729,864
of 25,986,827 outputs
Outputs from Brazilian Journal of Anesthesiology (English edition)
#1
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Outputs of similar age
#230,811
of 350,486 outputs
Outputs of similar age from Brazilian Journal of Anesthesiology (English edition)
#2
of 3 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 1.0. This one scored the same or higher as 0 of them.
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