Title |
Alternariol 9-methyl ether from the endophytic fungus Alternaria sp. Samif01 and its bioactivities
|
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Published in |
Brazilian Journal of Microbiology, January 2016
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DOI | 10.1016/j.bjm.2015.11.004 |
Pubmed ID | |
Authors |
Jingfeng Lou, Ruiting Yu, Xiaohan Wang, Ziling Mao, Linyun Fu, Yang Liu, Ligang Zhou |
Abstract |
One bioactive compound, identified as alternariol 9-methyl ether, was isolated from the crude extract of the endophytic fungus Alternaria sp. Samif01 residing in the roots of Salvia miltiorrhiza Bunge. Alternariol 9-methyl ether was active against bacteria with minimum inhibitory concentration values ranging from 25 to 75μg/mL and median inhibitory concentration (IC50) values ranging from 16.00 to 38.27μg/mL. The IC50 value of alternariol 9-methyl ether against spore germination of Magnaporthe oryzae was 87.18μg/mL. Alternariol 9-methyl ether also showed antinematodal activity against Bursaphelenchus xylophilus and Caenorhabditis elegans with IC50 values of 98.17μg/mL and 74.62μg/mL, respectively. This work is the first report on alternariol 9-methyl ether and its biological activities from the endophytic fungus Alternaria sp. Samif01 derived from S. miltiorrhiza Bunge. The results indicate the potential of Alternaria sp. Samif01 as a source of alternariol 9-methyl ether and also support that alternariol 9-methyl ether is a natural compound with high potential bioactivity against microorganisms. |
X Demographics
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 2% |
United States | 1 | 2% |
Unknown | 52 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 19% |
Student > Master | 9 | 17% |
Student > Bachelor | 7 | 13% |
Professor > Associate Professor | 3 | 6% |
Researcher | 3 | 6% |
Other | 5 | 9% |
Unknown | 17 | 31% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 17% |
Chemistry | 8 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Medicine and Dentistry | 4 | 7% |
Immunology and Microbiology | 3 | 6% |
Other | 7 | 13% |
Unknown | 18 | 33% |