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Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis

Overview of attention for article published in Brazilian Journal of Otorhinolaryngology, September 2015
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Title
Evaluation of the improvement of quality of life with Azithromycin in the treatment of eosinophilic nasal polyposis
Published in
Brazilian Journal of Otorhinolaryngology, September 2015
DOI 10.1016/j.bjorl.2015.03.018
Pubmed ID
Authors

Isamara Simas de Oliveira, Paulo Fernando Tormin Borges Crosara, Geovanni Dantas Cassali, Diego Carlos dos Reis, Camilo Brandão de Resende, Flavio Barbosa Nunes, Roberto Eustáquio Santos Guimarães

Abstract

The Sino-Nasal Outcome Test 22 (SNOT-22) is an important tool in assessing the quality of life (QoL) of patients with chronic rhinosinusitis with a validated version in Brazil. The eosinophilic nasal polyposis (ENP) represents most of the cases of nasal polyposis (85-90%) and belongs to the group of chronic rhinosinusitis. It is a chronic inflammatory disease that impacts the QoL of patients, not only causing localized symptoms, but also resulting in a general malaise. The standard treatments (corticosteroids and nasal endoscopic surgery) lead to partial control of symptoms, but relapses are frequent. Macrolide acting as an immunomodulator is a promising tool for more effective control of this disease. Studies are still lacking to assess the real impact on the QoL in patients treated with macrolides. To evaluate the improvement of QL, evaluated using SNOT-22, in patients with PNSE treated with immunomodulatory dose azithromycin. This is a paired experimental study in patients with ENP. Comparison of pre-treatment and post-treatment with azithromycin was performed. Patients completed the SNOT-22 questionnaire before the start of treatment and returned for evaluation after eight weeks of treatment. Azithromycin was prescribed at a dose of 500mg, orally, three times a week, for 8 weeks. SNOT-22 score decreased 20.3 points on average. There was a significant decrease in the SNOT-22 (difference greater than 14 points) in 19 patients (57.6%). There was no significant difference in improvement in SNOT in subgroups with or without asthma/aspirin intolerance. Azithromycin resulted in significant improvement of QoL, assessed by SNOT-22, in the studied population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 12%
Student > Bachelor 5 12%
Student > Ph. D. Student 4 10%
Researcher 3 7%
Student > Postgraduate 3 7%
Other 8 19%
Unknown 14 33%
Readers by discipline Count As %
Medicine and Dentistry 12 29%
Biochemistry, Genetics and Molecular Biology 4 10%
Nursing and Health Professions 3 7%
Chemistry 2 5%
Business, Management and Accounting 1 2%
Other 4 10%
Unknown 16 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2015.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Brazilian Journal of Otorhinolaryngology
#501
of 726 outputs
Outputs of similar age
#209,231
of 285,680 outputs
Outputs of similar age from Brazilian Journal of Otorhinolaryngology
#108
of 153 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 726 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,680 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.