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Suspected adverse drug reactions reported for Brazilian children: cross-sectional study

Overview of attention for article published in Jornal de Pediatria, July 2018
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Title
Suspected adverse drug reactions reported for Brazilian children: cross-sectional study
Published in
Jornal de Pediatria, July 2018
DOI 10.1016/j.jped.2018.05.019
Pubmed ID
Authors

Elisangela da Costa Lima, Guacira Corrêa de Matos, Jean M de L Vieira, Ivana C da C R Gonçalves, Lucio M Cabral, Mark A Turner

Abstract

To assess spontaneous reports of suspected adverse drug reactions (ADRs) in children aged 0-12 years from the Brazilian Health Regulatory Agency between 2008 and 2013. A cross-sectional study on suspected ADR reports related to medicines and health products in children was carried out for a six-year period (2008-2013). Year of report, origin of report by Brazilian state, gender, age, suspected drug, adverse reaction description and seriousness were included in the analysis. The data obtained was compared to the number of pediatric beds in health services and to global data from the VigiBase (WHO). A total of 3330 ADRs were reported in children in Brazil in the investigated period (54% were in boys). About 28% of suspected ADR reports involved 0 to 1-year-old children. Almost 40% of reports came from the Southeast region. Approximately 60% were classified as serious events. There was death in 75 cases. Nearly 30% of deaths involved off-label use; 3875 medicines (465 active substances) were considered suspected drugs. Anti-infective (vancomycin, ceftriaxone, oxacillin, and amphotericin), nervous system (metamizole) and alimentary tract and metabolism medicines were more frequent in reports. The distribution of suspected ADR reports by sex and age group corresponded to the profile of children hospitalized in Brazil. Data about seriousness and medicines reported may be useful to encourage regulatory actions and improve the safe use of medicines in children.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 11%
Student > Postgraduate 6 10%
Student > Master 6 10%
Student > Ph. D. Student 4 7%
Researcher 3 5%
Other 9 15%
Unknown 26 43%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 11 18%
Nursing and Health Professions 5 8%
Medicine and Dentistry 5 8%
Chemistry 3 5%
Agricultural and Biological Sciences 3 5%
Other 4 7%
Unknown 30 49%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2021.
All research outputs
#17,292,294
of 25,385,509 outputs
Outputs from Jornal de Pediatria
#498
of 897 outputs
Outputs of similar age
#219,979
of 340,475 outputs
Outputs of similar age from Jornal de Pediatria
#10
of 17 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 897 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,475 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.