Title |
Uso terapéutico de las vesículas extracelulares en insuficiencia renal aguda y crónica
|
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Published in |
Nefrología (Madrid), March 2017
|
DOI | 10.1016/j.nefro.2016.04.006 |
Pubmed ID | |
Authors |
Jordi Rovira, Fritz Diekmann, Josep M. Campistol, María José Ramírez-Bajo |
Abstract |
A new cell-to-cell communication system was discovered in the 1990s, which involves the release of vesicles into the extracellular space. These vesicles shuttle bioactive particles, including proteins, mRNA, miRNA, metabolites, etc. This particular communication has been conserved throughout evolution, which explains why most cell types are capable of producing vesicles. Extracellular vesicles (EVs) are involved in the regulation of different physiological processes, as well as in the development and progression of several diseases. EVs have been widely studied over recent years, especially those produced by embryonic and adult stem cells, blood cells, immune system and nervous system cells, as well as tumour cells. EV analysis from bodily fluids has been used as a diagnostic tool for cancer and recently for different renal diseases. However, this review analyses the importance of EVs generated by stem cells, their function and possible clinical application in renal diseases and kidney transplantation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 5 | 10% |
Student > Bachelor | 5 | 10% |
Student > Postgraduate | 5 | 10% |
Researcher | 4 | 8% |
Student > Ph. D. Student | 4 | 8% |
Other | 7 | 14% |
Unknown | 20 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 20% |
Agricultural and Biological Sciences | 7 | 14% |
Medicine and Dentistry | 6 | 12% |
Engineering | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Other | 3 | 6% |
Unknown | 19 | 38% |