Title |
Role of HIF-1α signaling pathway in osteoarthritis: a systematic review
|
---|---|
Published in |
Advances in Rheumatology, August 2016
|
DOI | 10.1016/j.rbre.2016.07.008 |
Pubmed ID | |
Authors |
Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, María Concepción Gutiérrez-Ruíz, Luis Enrique Gómez-Quiroz, Marwin Gutiérrez |
Abstract |
Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1α). HIF-1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF-1α in the scientific literature in the last years, we focused the present review on the potential role of HIF-1α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 17% |
Researcher | 6 | 13% |
Other | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 8 | 17% |
Unknown | 13 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 24% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Engineering | 4 | 9% |
Agricultural and Biological Sciences | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 6 | 13% |
Unknown | 14 | 30% |