Title |
Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat aorta
|
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Published in |
Journal of Venomous Animals and Toxins including Tropical Diseases, September 2013
|
DOI | 10.1186/1678-9199-19-24 |
Pubmed ID | |
Authors |
Paulo César P Sousa, Teresinha S Brito, Daniel S Freire, Rafael M Ximenes, Pedro Jorge C Magalhães, Helena SA Monteiro, Renata S Alves, Alice Maria C Martins, Daniela O Toyama, Marcos H Toyama |
Abstract |
Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. mellifera venom (AmV) affects mainly the cardiovascular system, and several works have described its actions on heart muscle. Nevertheless, no work on the pharmacological action mechanisms of the AmV in isolated aorta has been reported. Thus, the present work aimed to investigate the actions of AmV and its main fractions, phospholipase A2 (PLA2) and melittin, on isolated aorta rings and a probable action mechanism. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Yemen | 1 | 6% |
Brazil | 1 | 6% |
Unknown | 16 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 33% |
Student > Postgraduate | 4 | 22% |
Researcher | 3 | 17% |
Student > Bachelor | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 11% |
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Biochemistry, Genetics and Molecular Biology | 3 | 17% |
Medicine and Dentistry | 3 | 17% |
Social Sciences | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 22% |