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Mendeley readers
Attention Score in Context
| Title |
Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
|
|---|---|
| Published in |
Biological Research, June 2015
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| DOI | 10.1186/s40659-015-0020-0 |
| Pubmed ID | |
| Authors |
Rafael González-Alvarez, María de Lourdes Garza-Rodríguez, Iván Delgado-Enciso, Víctor Manuel Treviño-Alvarado, Ricardo Canales-Del-Castillo, Laura Elia Martínez-De-Villarreal, Ángel Lugo-Trampe, María Elizabeth Tejero, Natalia E. Schlabritz-Loutsevitch, María Del Refugio Rocha-Pizaña, Shelley A. Cole, Diana Reséndez-Pérez, Mario Moises-Alvarez, Anthony G. Comuzzie, Hugo Alberto Barrera-Saldaña, Raquel Garza-Guajardo, Oralia Barboza-Quintana, Irám Pablo Rodríguez-Sánchez |
| Abstract |
Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocyte-secreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. A RT-PCR from different tissues obtained during necropsies was performed. We tested the hypotheses of positive evolution, purifying selection, and neutrality. Also phylogenetic analysis was made between primates RARRES2 protein. RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. Conclusions RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 4% |
| Unknown | 23 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 4 | 17% |
| Professor > Associate Professor | 3 | 13% |
| Student > Ph. D. Student | 2 | 8% |
| Student > Doctoral Student | 2 | 8% |
| Researcher | 2 | 8% |
| Other | 7 | 29% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 21% |
| Agricultural and Biological Sciences | 4 | 17% |
| Medicine and Dentistry | 3 | 13% |
| Engineering | 2 | 8% |
| Immunology and Microbiology | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 6 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2015.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Biological Research
#326
of 642 outputs
Outputs of similar age
#166,479
of 278,770 outputs
Outputs of similar age from Biological Research
#5
of 16 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,770 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.