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Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2017
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Title
Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
Published in
Anais da Academia Brasileira de Ciências, May 2017
DOI 10.1590/0001-3765201720160483
Pubmed ID
Authors

IBRAHIM CHAHOUD, FRANCISCO J.R. PAUMGARTTEM

Abstract

The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI: GD 9, 91/2 or 10; DBA/2J: GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 14%
Student > Bachelor 1 14%
Student > Postgraduate 1 14%
Student > Master 1 14%
Unknown 3 43%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Nursing and Health Professions 1 14%
Agricultural and Biological Sciences 1 14%
Computer Science 1 14%
Engineering 1 14%
Other 0 0%
Unknown 2 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2017.
All research outputs
#23,320,957
of 25,988,468 outputs
Outputs from Anais da Academia Brasileira de Ciências
#197
of 217 outputs
Outputs of similar age
#288,521
of 328,678 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#1
of 1 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 217 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,678 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
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