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X Demographics
Mendeley readers
| Title |
Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
|
|---|---|
| Published in |
Anais da Academia Brasileira de Ciências, August 2018
|
| DOI | 10.1590/0001-3765201820170762 |
| Pubmed ID | |
| Authors |
RODRIGO M. DA COSTA, KARINA KARMIRIAN, STEVENS K. REHEN |
| Abstract |
Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders. Recently we showed changes in shape and membrane potential in mitochondria from human neural progenitor cells (NPCs) exposed to VPA (da Costa et al. 2015). Here, we applied transmission electron microscopy and electron tomography to evaluate mitochondrial damage caused by VPA in NPCs. Results showed mitochondrial cristae disorganization in a dose dependent manner. Disturbance in mitochondrial ultrastructure may influence metabolism, leading to synaptic plasticity and neurogenesis impairment. These data contribute to understanding VPA exposure potential effects on brain development. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 11% |
| Student > Postgraduate | 4 | 11% |
| Student > Doctoral Student | 4 | 11% |
| Student > Bachelor | 3 | 9% |
| Researcher | 3 | 9% |
| Other | 9 | 26% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 29% |
| Biochemistry, Genetics and Molecular Biology | 7 | 20% |
| Medicine and Dentistry | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 29% |