Title |
Neuroinflammation in the pathophysiology of Parkinson’s disease and therapeutic evidence of anti-inflammatory drugs
|
---|---|
Published in |
Arquivos de Neuro-Psiquiatria, July 2015
|
DOI | 10.1590/0004-282x20150057 |
Pubmed ID | |
Authors |
Taysa Bervian Bassani, Maria A.B.F. Vital, Laryssa K. Rauh |
Abstract |
Parkinson's disease (PD) is the second most common neurodegenerative disease affecting approximately 1.6% of the population over 60 years old. The cardinal motor symptoms are the result of progressive degeneration of substantia nigra pars compacta dopaminergic neurons which are involved in the fine motor control. Currently, there is no cure for this pathology and the cause of the neurodegeneration remains unknown. Several studies suggest the involvement of neuroinflammation in the pathophysiology of PD as well as a protective effect of anti-inflammatory drugs both in animal models and epidemiological studies, although there are controversial reports. In this review, we address evidences of involvement of inflammatory process and possible therapeutic usefulness of anti-inflammatory drugs in PD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 123 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 20% |
Student > Ph. D. Student | 16 | 13% |
Student > Bachelor | 16 | 13% |
Researcher | 11 | 9% |
Student > Doctoral Student | 10 | 8% |
Other | 18 | 15% |
Unknown | 28 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 21 | 17% |
Agricultural and Biological Sciences | 20 | 16% |
Biochemistry, Genetics and Molecular Biology | 13 | 10% |
Medicine and Dentistry | 13 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 8% |
Other | 15 | 12% |
Unknown | 32 | 26% |