Title |
Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole
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Published in |
Arquivos de Neuro-Psiquiatria, September 2015
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DOI | 10.1590/0004-282x20150121 |
Pubmed ID | |
Authors |
Akbar Anaeigoudari, Mohammad Naser Shafei, Mohammad Soukhtanloo, Hamid Reza Sadeghnia, Parham Reisi, Farimah Beheshti, Reza Mohebbati, Seyed Mojtaba Mousavi, Mahmoud Hosseini |
Abstract |
Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 13% |
Student > Doctoral Student | 4 | 13% |
Student > Bachelor | 3 | 10% |
Other | 3 | 10% |
Student > Master | 3 | 10% |
Other | 5 | 17% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 13% |
Agricultural and Biological Sciences | 3 | 10% |
Psychology | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Chemistry | 2 | 7% |
Other | 4 | 13% |
Unknown | 12 | 40% |