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The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, August 2016
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Title
The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population
Published in
Arquivos de Neuro-Psiquiatria, August 2016
DOI 10.1590/0004-282x20160100
Pubmed ID
Authors

Lineu Cesar Werneck, Paulo José Lorenzoni, Raquel Cristina Arndt, Cláudia Suemi Kamoi Kay, Rosana Herminia Scola

Abstract

To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil. We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles with high resolution techniques. We found a lower frequency of all HLA alleles class 1 and 2 in MS and controls comparing to the European population. Several alleles had statistical correlation, but after Bonferroni correction, the only allele with significance was the HLA-DQB1*02:03, which has a positive association with MS. Our data have different frequency of HLA-alleles than the previous published papers in the Southeast Brazil and European population, possible due to several ethnic backgrounds.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Student > Master 3 14%
Student > Doctoral Student 2 10%
Researcher 2 10%
Student > Ph. D. Student 2 10%
Other 3 14%
Unknown 4 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 19%
Nursing and Health Professions 2 10%
Agricultural and Biological Sciences 2 10%
Neuroscience 2 10%
Medicine and Dentistry 2 10%
Other 5 24%
Unknown 4 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#1,141
of 1,369 outputs
Outputs of similar age
#339,043
of 381,020 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#16
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.