Title |
The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population
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Published in |
Arquivos de Neuro-Psiquiatria, August 2016
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DOI | 10.1590/0004-282x20160100 |
Pubmed ID | |
Authors |
Lineu Cesar Werneck, Paulo José Lorenzoni, Raquel Cristina Arndt, Cláudia Suemi Kamoi Kay, Rosana Herminia Scola |
Abstract |
To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil. We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles with high resolution techniques. We found a lower frequency of all HLA alleles class 1 and 2 in MS and controls comparing to the European population. Several alleles had statistical correlation, but after Bonferroni correction, the only allele with significance was the HLA-DQB1*02:03, which has a positive association with MS. Our data have different frequency of HLA-alleles than the previous published papers in the Southeast Brazil and European population, possible due to several ethnic backgrounds. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 24% |
Student > Master | 3 | 14% |
Student > Doctoral Student | 2 | 10% |
Researcher | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 3 | 14% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Nursing and Health Professions | 2 | 10% |
Agricultural and Biological Sciences | 2 | 10% |
Neuroscience | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Other | 5 | 24% |
Unknown | 4 | 19% |