To describe the evolution of 15 patients who were treated for difficult-to-control episodic and chronic cluster headaches with clomiphene.
Clomiphene treatment was used for seven chronic and eight episodic cluster headache patients. The chronic patients were refractory to the medication being used, and the episodic patients, in addition to being resistant to conventional medication, had longer cluster headache periods, exceeding the average time of previous cluster cycles. Our main analysis was of the time to pain-free, complete remission, and the length of pain-free time and complete remission.
Clomiphene was used for 45-180 days. The average time to being pain-free was 15 days and cluster remission was up to 60 days. The average time between being pain-free until cluster remission was 26 days.
Clomiphene treatment was significantly efficient. It interrupted chronicity in all patients, suggesting the capability of changing the pattern of attacks. It proved to be safe and well tolerated.
Pharmacology, Toxicology and Pharmaceutical Science
1
5%
Biochemistry, Genetics and Molecular Biology
1
5%
Agricultural and Biological Sciences
1
5%
Other
1
5%
Unknown
6
29%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2024.
All research outputs
#6,747,700
of 33,087,078 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#224
of 1,642 outputs
Outputs of similar age
#80,460
of 346,472 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#1
of 17 outputs
Altmetric has tracked 33,087,078 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,642 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.
