Title |
MOG-IgG associated optic neuritis is not multiple sclerosis
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Published in |
Arquivos de Neuro-Psiquiatria, October 2017
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DOI | 10.1590/0004-282x20170121 |
Pubmed ID | |
Authors |
Bruna Klein da Costa, Giordani Rodrigues dos Passos, Jefferson Becker, Douglas Kazutoshi Sato |
Abstract |
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay. When compared with the MS group, the MOG-IgG patients were older (mean 47 years), more frequently male (ratio 2:1) and had a higher frequency of bilateral and/or recurrent ON. The brain magnetic resonance imaging of all MOG-IgG positive patients was normal or had only unspecific white matter T2 lesions. These findings suggest that MOG-IgG is a biomarker of an inflammatory demyelinating CNS disease distinct from MS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 16% |
Researcher | 5 | 16% |
Other | 4 | 13% |
Student > Master | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 2 | 6% |
Unknown | 11 | 34% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 47% |
Agricultural and Biological Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Physics and Astronomy | 1 | 3% |
Neuroscience | 1 | 3% |
Other | 0 | 0% |
Unknown | 11 | 34% |