Title |
The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study
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Published in |
Memórias do Instituto Oswaldo Cruz, June 2017
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DOI | 10.1590/0074-02760160355 |
Pubmed ID | |
Authors |
Laura Infurnari, Laura Galli, Alba Bigoloni, Alessia Carbone, Stefania Chiappetta, Angelo Sala, Norberto Ceserani, Adriano Lazzarin, Antonella Castagna, Giovanni Gaiera/ |
Abstract |
Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 19% |
Student > Bachelor | 6 | 13% |
Researcher | 5 | 10% |
Lecturer | 4 | 8% |
Other | 4 | 8% |
Other | 10 | 21% |
Unknown | 10 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 25% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Immunology and Microbiology | 6 | 13% |
Agricultural and Biological Sciences | 5 | 10% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 3 | 6% |
Unknown | 14 | 29% |