Title |
Emergence of Trichosporon mycotoxinivorans (Apiotrichum mycotoxinivorans) invasive infections in Latin America
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Published in |
Memórias do Instituto Oswaldo Cruz, October 2017
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DOI | 10.1590/0074-02760170011 |
Pubmed ID | |
Authors |
João Nobrega de Almeida, Elaine Cristina Francisco, Maria Goreth M de Andrade Barberino, Luiz Vicente Ribeiro F da Silva, Oriana M Brandão, Arnaldo Lopes Colombo, Ana Carolina Barbosa Padovan |
Abstract |
We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. A review of the relevant literature revealed that deep-seated infections were related to immunosuppression or invasive devices, while most of the CF patients showed a decline in lung function after positive cultures. Phylogenetic analyses revealed three distinct circulating genotypes. MALDI-TOF mass spectrometry analysis showed similar spectral profiles and correctly identified all strains/isolates. Biofilm production was documented in a bloodstream isolate and biofilm-producing cells showed high minimum inhibitory concentrations against antifungals. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 20% |
Student > Postgraduate | 3 | 15% |
Student > Ph. D. Student | 2 | 10% |
Unspecified | 1 | 5% |
Student > Bachelor | 1 | 5% |
Other | 0 | 0% |
Unknown | 9 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Immunology and Microbiology | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Agricultural and Biological Sciences | 1 | 5% |
Unspecified | 1 | 5% |
Other | 2 | 10% |
Unknown | 9 | 45% |