Title |
Peeling the onion: the outer layers of Cryptococcus neoformans
|
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Published in |
Memórias do Instituto Oswaldo Cruz, May 2018
|
DOI | 10.1590/0074-02760180040 |
Pubmed ID | |
Authors |
Daniel P Agustinho, Liza C Miller, Lucy X Li, Tamara L Doering |
Abstract |
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 25% |
United States | 1 | 25% |
Netherlands | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 20% |
Student > Ph. D. Student | 10 | 12% |
Student > Master | 10 | 12% |
Student > Doctoral Student | 4 | 5% |
Professor | 4 | 5% |
Other | 9 | 11% |
Unknown | 28 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 16% |
Agricultural and Biological Sciences | 10 | 12% |
Immunology and Microbiology | 7 | 9% |
Chemistry | 4 | 5% |
Computer Science | 2 | 2% |
Other | 12 | 15% |
Unknown | 33 | 41% |