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The first report of the vanC1 gene in Enterococcus faecium isolated from a human clinical specimen

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, September 2014
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Title
The first report of the vanC1 gene in Enterococcus faecium isolated from a human clinical specimen
Published in
Memórias do Instituto Oswaldo Cruz, September 2014
DOI 10.1590/0074-0276140019
Pubmed ID
Authors

Mingyue Sun, Yue Wang, Zhongju Chen, Xuhui Zhu, Lei Tian, Ziyong Sun

Abstract

The vanC₁ gene, which is chromosomally located, confers resistance to vancomycin and serves as a species marker for Enterococcus gallinarum. Enterococcus faecium TJ4031 was isolated from a blood culture and harbours the vanC₁gene. Polymerase chain reaction (PCR) assays were performed to detect vanXYc and vanTc genes. Only the vanXYc gene was found in the E. faecium TJ4031 isolate. The minimum inhibitory concentrations of vancomycin and teicoplanin were 2 µg/mL and 1 µg/mL, respectively. Real-time reverse transcription-PCR results revealed that the vanC₁ and vanXYc genes were not expressed. Pulsed-field gel electrophoresis and southern hybridisation results showed that the vanC₁ gene was encoded in the chromosome. E. faecalis isolated from animals has been reported to harbour vanC₁gene. However, this study is the first to report the presence of the vanC₁gene in E. faecium of human origin. Additionally, our research showed the vanC₁gene cannot serve as a species-specific gene of E. gallinarum and that it is able to be transferred between bacteria. Although the resistance marker is not expressed in the strain, our results showed that E. faecium could acquire the vanC₁gene from different species.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
India 1 3%
Brazil 1 3%
Unknown 32 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 17%
Student > Master 6 17%
Student > Ph. D. Student 4 11%
Student > Bachelor 4 11%
Student > Doctoral Student 3 9%
Other 7 20%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 34%
Medicine and Dentistry 8 23%
Immunology and Microbiology 4 11%
Biochemistry, Genetics and Molecular Biology 2 6%
Business, Management and Accounting 1 3%
Other 3 9%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2015.
All research outputs
#18,416,517
of 22,813,792 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,065
of 1,377 outputs
Outputs of similar age
#169,092
of 237,323 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#22
of 29 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.