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Metabolomics in the fight against malaria

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, August 2014
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Title
Metabolomics in the fight against malaria
Published in
Memórias do Instituto Oswaldo Cruz, August 2014
DOI 10.1590/0074-0276140043
Pubmed ID
Authors

Jorge L Salinas, Jessica C Kissinger, Dean P Jones, Mary R Galinski

Abstract

Metabolomics uses high-resolution mass spectrometry to provide a chemical fingerprint of thousands of metabolites present in cells, tissues or body fluids. Such metabolic phenotyping has been successfully used to study various biologic processes and disease states. High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium life cycle and the downstream ramifications on the host's metabolism, pathogenesis and disease. Such data can become integrated with other large datasets generated using top-down systems biology approaches and be utilised by computational biologists to develop and enhance models of malaria pathogenesis relevant for identifying new drug targets or intervention strategies. Here, we focus on the promise of metabolomics to complement systems biology approaches in the quest for novel interventions in the fight against malaria. We introduce the Malaria Host-Pathogen Interaction Center (MaHPIC), a new systems biology research coalition. A primary goal of the MaHPIC is to generate systems biology datasets relating to human and non-human primate (NHP) malaria parasites and their hosts making these openly available from an online relational database. Metabolomic data from NHP infections and clinical malaria infections from around the world will comprise a unique global resource.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Brazil 2 2%
Canada 1 <1%
India 1 <1%
Unknown 116 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 24%
Student > Master 15 12%
Researcher 14 11%
Student > Bachelor 13 11%
Student > Postgraduate 8 7%
Other 19 15%
Unknown 24 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 24%
Biochemistry, Genetics and Molecular Biology 19 15%
Medicine and Dentistry 12 10%
Computer Science 6 5%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Other 20 16%
Unknown 31 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#16,046,765
of 25,371,288 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#953
of 1,502 outputs
Outputs of similar age
#128,670
of 240,208 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#19
of 36 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,208 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.