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Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder

Overview of attention for article published in Revista Brasileira de Psiquiatria, February 2016
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Title
Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder
Published in
Revista Brasileira de Psiquiatria, February 2016
DOI 10.1590/1516-4446-2015-1801
Pubmed ID
Authors

Fabiano G. Nery, Alexandre D. Gigante, Jose A. Amaral, Francy B. Fernandes, Mariangeles Berutti, Karla M. Almeida, Laura Stertz, Giovana Bristot, Flavio Kapczinski, Beny Lafer

Abstract

Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease. Brain-derived neurotrophic factor (BDNF) is considered to be implicated in the pathophysiology of BD, but its role as an endophenotype has been poorly studied. We investigated abnormal serum BDNF levels in BD patients, in their unaffected relatives, and in healthy controls. BDNF levels were obtained from 25 DSM-IV bipolar I disorder patients, 23 unaffected relatives, and 27 healthy controls. All BD patients were in remission. The unaffected subjects were first-degree relatives of the proband who had no lifetime DSM-IV diagnosis of axis I disorder. BDNF serum levels were determined by sandwich ELISA using monoclonal BDNF-specific antibodies. There were no statistical differences in BDNF levels among BD patients, relatives, and healthy controls. Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 14%
Student > Ph. D. Student 3 11%
Student > Bachelor 2 7%
Researcher 2 7%
Student > Postgraduate 2 7%
Other 6 21%
Unknown 9 32%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Psychology 3 11%
Biochemistry, Genetics and Molecular Biology 2 7%
Unspecified 2 7%
Neuroscience 2 7%
Other 4 14%
Unknown 9 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2016.
All research outputs
#20,660,571
of 25,377,790 outputs
Outputs from Revista Brasileira de Psiquiatria
#707
of 902 outputs
Outputs of similar age
#300,501
of 406,037 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#13
of 19 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 902 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.