Title |
RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
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Published in |
Genetics and Molecular Biology, January 2017
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DOI | 10.1590/1678-4685-gmb-2016-0258 |
Pubmed ID | |
Authors |
Camila Oliveira, Helisson Faoro, Lysangela Ronalte Alves, Samuel Goldenberg |
Abstract |
RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 131 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 18% |
Student > Bachelor | 23 | 18% |
Student > Master | 19 | 15% |
Researcher | 10 | 8% |
Student > Doctoral Student | 6 | 5% |
Other | 6 | 5% |
Unknown | 43 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 46 | 35% |
Agricultural and Biological Sciences | 19 | 15% |
Immunology and Microbiology | 4 | 3% |
Neuroscience | 3 | 2% |
Chemistry | 3 | 2% |
Other | 9 | 7% |
Unknown | 47 | 36% |