Title |
Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin
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Published in |
Brazilian Oral Research, April 2016
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DOI | 10.1590/1807-3107bor-2016.vol30.0061 |
Pubmed ID | |
Authors |
Daniel Rodrigo Herrera, Jorge Enrique Durand-Ramirez, Amanda Falcão, Emmanuel João Leal Nogueira da Silva, Elizabete Brasil Dos Santos, Brenda Paula Figueiredo de Almeida Gomes |
Abstract |
The aim of this study was to analyze the antimicrobial activity and substantivity of Uncaria tomentosa Willd DC (cat's claw, CC) in root dentin contaminated with Enterococcus faecalis. Forty-eight human premolars were contaminated with E. faecalis (ATCC 29212) and randomly divided into four groups according to the irrigant used during chemomechanical preparation (CMP): CC group: 2% CC gel; CHX group: 2% chlorhexidine digluconate gel (CHX); NaOCl group: 5.25% sodium hypochlorite (NaOCl); and SS group: sterile saline (SS). Microbiological samples were collected before (S1) and after (S2) CMP and after 7 days (S3). Colony-forming units (CFU/mL) at the different sampling times and comparisons among the groups were statistically analyzed by Wilcoxon and Kruskal-Wallis tests (p < 0.05). Significant bacterial reduction was achieved in all groups after CMP (p < 0.05). Results show no significant difference between S3 and S2 (p > 0.05) in the CC and CHX groups. Bacterial load was higher in S3 than in S2 samples (p < 0.05) in the NaOCl and SS groups. Our results suggest antibacterial effect of 2% CC gel against E. faecalis in infected dentin, in addition to antibacterial substantivity of 2% CC and 2% CHX up to 7 days. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Uruguay | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 70 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 15% |
Unspecified | 9 | 13% |
Student > Master | 9 | 13% |
Student > Bachelor | 8 | 11% |
Student > Ph. D. Student | 5 | 7% |
Other | 14 | 20% |
Unknown | 15 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 37% |
Unspecified | 9 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Chemistry | 3 | 4% |
Neuroscience | 3 | 4% |
Other | 8 | 11% |
Unknown | 18 | 25% |