CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION
Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers.
The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori.
In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks.
Triple therapy with curcumin treatment group significantly decreased malondialdehyde markers, glutathione peroxides and increased total antioxidant capacity of the gastric mucosa at the end of study compared to baseline and triple regimen groups. In addition, the oxidative damage to DNA was significantly decreased in triple therapy with curcumin group at the end of study compared to baseline and compared to triple therapy (P<0.05 for both). Triple therapy group in combination with Curcumin significantly decreased all active, chronic and endoscopic inflammation scores of patients compared to the baseline and triple therapy group (P<0.05 for both). The eradication rate by triple therapy + curcumin was significantly increased compared to triple therapy alone (P<0.05).
Curcumin can be a useful supplement to improve chronic inflammation and prevention of carcinogenic changes in patients with chronic gastritis associated by H. pylori.
Pharmacology, Toxicology and Pharmaceutical Science
2
7%
Immunology and Microbiology
2
7%
Biochemistry, Genetics and Molecular Biology
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4%
Nursing and Health Professions
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4%
Other
3
11%
Unknown
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52%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#4,752,007
of 27,578,965 outputs
Outputs from Arquivos de Gastroenterologia
#28
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Outputs of similar age
#71,791
of 331,616 outputs
Outputs of similar age from Arquivos de Gastroenterologia
#2
of 6 outputs
Altmetric has tracked 27,578,965 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 419 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 93% of its peers.
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