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CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families

Overview of attention for article published in Arquivos de Gastroenterologia, January 2013
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Title
CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families
Published in
Arquivos de Gastroenterologia, January 2013
DOI 10.1590/s0004-28032012000400008
Pubmed ID
Authors

Jamile Abud, João Carlos Prolla, Patrícia Koehler-Santos, Patricia Ashton-Prolla

Abstract

CHEK2 encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage repair pathway, activated mainly by ATM (Ataxia Telangiectasia Mutated) in response to double-stranded DNA breaks. A germline mutation in CHEK2, 1100delC, has been described as a low penetrance allele in a significant number of families with breast and colorectal cancer in certain countries and is also associated with increased risk of contralateral breast cancer in women previously affected by the disease. About 5%-10% of all breast and colorectal cancers are associated with hereditary predisposition and its recognition is of great importance for genetic counseling and cancer risk management.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 18%
Researcher 8 16%
Student > Master 7 14%
Student > Ph. D. Student 4 8%
Professor > Associate Professor 4 8%
Other 7 14%
Unknown 11 22%
Readers by discipline Count As %
Medicine and Dentistry 13 26%
Biochemistry, Genetics and Molecular Biology 10 20%
Agricultural and Biological Sciences 7 14%
Computer Science 2 4%
Unspecified 1 2%
Other 4 8%
Unknown 13 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Arquivos de Gastroenterologia
#223
of 378 outputs
Outputs of similar age
#231,411
of 292,326 outputs
Outputs of similar age from Arquivos de Gastroenterologia
#6
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 378 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,326 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.