CHEK2 encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage repair pathway, activated mainly by ATM (Ataxia Telangiectasia Mutated) in response to double-stranded DNA breaks. A germline mutation in CHEK2, 1100delC, has been described as a low penetrance allele in a significant number of families with breast and colorectal cancer in certain countries and is also associated with increased risk of contralateral breast cancer in women previously affected by the disease. About 5%-10% of all breast and colorectal cancers are associated with hereditary predisposition and its recognition is of great importance for genetic counseling and cancer risk management.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Arquivos de Gastroenterologia
#223
of 378 outputs
Outputs of similar age
#231,411
of 292,326 outputs
Outputs of similar age from Arquivos de Gastroenterologia
#6
of 10 outputs
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So far Altmetric has tracked 378 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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