Title |
Multiple sclerosis: clinical and laboratorial correlation
|
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Published in |
Arquivos de Neuro-Psiquiatria, April 2001
|
DOI | 10.1590/s0004-282x2001000100018 |
Pubmed ID | |
Authors |
Marzia Puccioni-Sohler, Fabiola Passeri Lavrado, Reizer Reis Gonçalves Bastos, Carlos Otávio Brandão, Regina Papaiz-Alvarenga |
Abstract |
The clinical and demographic characteristics of 86 Brazilian patients with clinically definite multiple sclerosis (MS) were compared to the cerebrospinal fluid (CSF) findings. The disease course was relapsing-remitting in 71% and chronic progressive in 29% of the cases. The IgG index was increased in 76% in the chronic progressive status and 46% and 49% during the bout and remission, respectively (p < 0.005). Only 36% of the MS patients using corticosteroids had increased IgG index, in comparison to the 64% of the patients without immunosupressive treatment. Oligoclonal IgG bands were detected in the CSF of 77% and 88% of the MS corticosteroids users and non-users, respectively. The quantitative study of intrathecal synthesis of IgG contributes to demonstrate the immunological differences between the two forms of MS, the relapsing-remitting and the chronic progressive. The treatment with corticosteroids decreases quantitatively the intrathecal synthesis of IgG but not the presence of oligoclonal bands. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 15% |
Unknown | 17 | 85% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 35% |
Other | 2 | 10% |
Researcher | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 2 | 10% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 25% |
Agricultural and Biological Sciences | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Neuroscience | 1 | 5% |
Materials Science | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |