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Efficacy of three drugs in the treatment of migrainous aura: a randomized, placebo-controlled study

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, July 2002
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Title
Efficacy of three drugs in the treatment of migrainous aura: a randomized, placebo-controlled study
Published in
Arquivos de Neuro-Psiquiatria, July 2002
DOI 10.1590/s0004-282x2002000300013
Pubmed ID
Authors

Marcelo E. Bigal, Carlos A. Bordini, José Geraldo Speciali

Abstract

In spite of the enormous amount of research regarding classification, epidemiology, diagnosis, pathophysiology and treatment of migraines, aura, one of its hallmarks, stays much less studied. The objective of this study is, therefore, to evaluate the evolution of aura in patients submitted to placebo and three different drugs available in Brazilian public health units. We studied 86 patients during an acute migrainous attack, with aura at the moment of the evaluation. Patients were randomized to receive one of the following substances, in a parenteral route: placebo, dipyrone, chlorpromazine and magnesium sulphate. Magnesium sulphate was superior to placebo (p <0,05) 30 and 60 minutes after its administration. Dipyrone and chlorpromazine reduced the duration of the aura, when compared to placebo, 60 minutes following their administration. Our findings make possible some speculations about the pathophysiology of migraine, as well as about the therapeutic approach of patients presenting migrainous aura.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Other 3 17%
Student > Postgraduate 3 17%
Researcher 3 17%
Student > Ph. D. Student 2 11%
Student > Master 2 11%
Other 3 17%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 11 61%
Nursing and Health Professions 2 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Sports and Recreations 1 6%
Design 1 6%
Other 0 0%
Unknown 2 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2022.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#1,141
of 1,369 outputs
Outputs of similar age
#46,348
of 47,402 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#9
of 12 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 47,402 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.