Title |
Dementia Pugilistica with clinical features of Alzheimer's disease
|
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Published in |
Arquivos de Neuro-Psiquiatria, April 2008
|
DOI | 10.1590/s0004-282x2007000500019 |
Pubmed ID | |
Authors |
Renata Areza-Fegyveres, Sergio Rosemberg, Rosa Maria R.P.S. Castro, Claudia Sellitto Porto, Valéria Santoro Bahia, Paulo Caramelli, Ricardo Nitrini |
Abstract |
A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease. |
X Demographics
Geographical breakdown
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Mexico | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 1% |
Unknown | 67 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 12 | 18% |
Student > Bachelor | 11 | 16% |
Student > Ph. D. Student | 8 | 12% |
Researcher | 6 | 9% |
Other | 5 | 7% |
Other | 15 | 22% |
Unknown | 11 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 16% |
Neuroscience | 11 | 16% |
Psychology | 9 | 13% |
Agricultural and Biological Sciences | 6 | 9% |
Sports and Recreations | 5 | 7% |
Other | 10 | 15% |
Unknown | 16 | 24% |