Title |
Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients
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Published in |
Arquivos de Neuro-Psiquiatria, October 2008
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DOI | 10.1590/s0004-282x2008000500012 |
Pubmed ID | |
Authors |
Soniza Vieira Alves-Leon, Fabíola Rachid Malfetano, Maria Lucia Veluttini Pimentel, Claudio Luiz Duque Estrada, Valéria Coelho Santa Rita Pereira, Assuncíon Martinez Liem, Sérgio Augusto Pereira Novis |
Abstract |
We studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0+/-10.3), mainly Caucasians (82/67%). The relapsing-remitting course (MSRR) was more frequent (106/86.8%). Monosymptomatic onset was significantly more frequent in Caucasians than in Afro-Brazilians (p<0.05). Seventeen patients had benign form of MS and these patients presented association with MSRR when compared with severe form (p=0.01). The mortality rate was 2.12% (4 patients died). This study was similar to other Brazilian series with regard to sex and age, and lack of correlation between EDSS and number of relapses; it confirmed south-southeast African-descendants gradient distribution and association between first mono-symptomatic relapses and Caucasian; we found lower frequency of benign forms. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 14% |
Student > Ph. D. Student | 6 | 12% |
Researcher | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Other | 11 | 22% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 37% |
Neuroscience | 6 | 12% |
Agricultural and Biological Sciences | 5 | 10% |
Unspecified | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 13 | 27% |