Title |
Indications of carbapenem resistance evolution through heteroresistance as an intermediate stage in Acinetobacter baumannii after carbapenem administration
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, April 2009
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DOI | 10.1590/s0036-46652009000200010 |
Pubmed ID | |
Authors |
Silvana Vargas Superti, Daniela de Souza Martins, Juliana Caierão, Fabiana da Silva Soares, Taísa Prochnow, Alexandre Prehn Zavascki |
Abstract |
We describe an in vivo evolution of an antimicrobial profile from susceptibility to full-resistance to carbapenems, with heteroresistance as an intermediate stage, in an Acinetobacter baumannii strain. Heteroresistance was characterized by the growth of sub-populations within the susceptibility halo in both disk-diffusion and Etest. PCRs for the main A. baumannii carbapenemases were negative. The exact resistance mechanism, diagnostic methods and clinical relevance of heteroresistance in A. baumannii warrant further investigations. This is the first description of such phenomenon in vivo and the second report of heteroresistance to carbapenems in A. baumannii. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 19% |
Student > Bachelor | 5 | 12% |
Researcher | 5 | 12% |
Student > Doctoral Student | 3 | 7% |
Other | 3 | 7% |
Other | 9 | 21% |
Unknown | 9 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 29% |
Agricultural and Biological Sciences | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Immunology and Microbiology | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 3 | 7% |
Unknown | 11 | 26% |