Title |
INTERFERON BETA-1A TREATMENT IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS: A CASE REPORT
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, January 2014
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DOI | 10.1590/s0036-46652014000500013 |
Pubmed ID | |
Authors |
Graça Maria de Castro Viana, Marcos Antonio Custódio Neto da Silva, Victor Lima Souza, Natália Barbosa da Silva Lopes, Diego Luz Felipe da Silva, Maria do Desterro Soares Brandão Nascimento |
Abstract |
Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and laboratory tests confirmed the presence of antibodies to HTLV-1 in the cerebrospinal fluid (CSF). Mumps, cytomegalovirus, Epstein-Barr virus, schistosomiasis, herpes virus 1 and 2, rubella, measles, varicella-zoster toxoplasmosis, hepatitis, HIV, and syphilis were excluded by serology. The patient was diagnosed with neurogenic bladder and presented with nocturia, urinary urgency, paresthesia of the lower left limb, a marked reduction of muscle strength in the lower limbs, and a slight reduction in upper limb strength. During the fourth week of treatment with interferon beta-1a, urinary urgency and paresthesia disappeared and clinical motor skills improved. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 22% |
Other | 1 | 6% |
Student > Master | 1 | 6% |
Unknown | 12 | 67% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Unknown | 13 | 72% |