Title |
Necrolytic migratory erythema associated with glucagonoma syndrome: a case report
|
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Published in |
Clinics, February 2002
|
DOI | 10.1590/s0041-87812001000600005 |
Pubmed ID | |
Authors |
Cassio C. Dal Coleto, Ana Paula F. de Mello, Jaime Piquero-Casals, Fábio R. Lima, Maria Aparecida Constantino Vilela, Cyro Festa-Neto, José Antonio Sanches |
Abstract |
Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female patient with necrolytic migratory erythema associated with glucagonoma syndrome who had metastatic disease at presentation and passed away one week after her admission. The autopsy showed a tumor in the body of the pancreas, which was diagnosed as a neuroendocrine tumor and confirmed by immunohistochemistry. The diagnosis of necrolytic migratory erythema is a matter of great importance, since it might be an auxiliary tool for the early detection of glucagonoma. |
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