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Mendeley readers
| Title |
A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, June 2009
|
| DOI | 10.1590/s0074-02761992000700011 |
| Pubmed ID | |
| Authors |
D. J. Kemp, J. Thompson, D. A. Barnes, T. Triglia, F. Karamalis, C. Petersen, G. V. Brown, K. P. Day |
| Abstract |
Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocytes. The deletion also results in loss of expression of PfEMP1, the putative cytoadherence ligand, suggesting that PfEMP1 or a regulatory gene controlling PfEMP1 expression and gametocytogenesis may be encoded in this region. We have isolated several markers for the deleted region and are currently using a YAC-P. falciparum library to investigate this region of the genome in detail. |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 10% |
| Malaysia | 1 | 5% |
| Kenya | 1 | 5% |
| Unknown | 16 | 80% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 40% |
| Researcher | 5 | 25% |
| Professor | 3 | 15% |
| Student > Doctoral Student | 2 | 10% |
| Student > Postgraduate | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 65% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Computer Science | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 1 | 5% |