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Mendeley readers
Attention Score in Context
| Title |
Cytotoxicity and potential antiviral evaluation of violacein produced by Chromobacterium violaceum
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, October 2003
|
| DOI | 10.1590/s0074-02762003000600023 |
| Pubmed ID | |
| Authors |
CR Andrighetti-Fröhner, RV Antonio, TB Creczynski-Pasa, CRM Barardi, CMO Simões |
| Abstract |
Natural products are an inexhaustible source of compounds with promising pharmacological activities including antiviral action. Violacein, the major pigment produced by Chromobacterium violaceum, has been shown to have antibiotic, antitumoral and anti-Trypanosoma cruzi activities. The goal of the present work was to evaluate the cytotoxicity of violacein and also its potential antiviral properties. The cytotoxicity of violacein was investigated by three methods: cell morphology evaluation by inverted light microscopy and cell viability tests using the Trypan blue dye exclusion method and the MTT assay. The cytotoxic concentration values which cause destruction in 50% of the monolayer cells (CC50) were different depending on the sensitivity of the method. CC50 values were > or =2.07 +/- 0.08 microM for FRhK-4 cells: > or =2.23 +/- 0.11 microM for Vero cells; > or =2.54 +/- 0.18 microM for MA104 cells; and > or =2.70 +/- 0.20 microM for HEp-2 cells. Violacein showed no cytopathic inhibition of the following viruses: herpes simplex virus type 1 (HSV-1) strain 29-R/acyclovir resistant, hepatitis A virus (strains HM175 and HAF-203) and adenovirus type 5 nor did it show any antiviral activity in the MTT assay. However violacein did show a weak inhibition of viral replication: 1.42 +/- 0.68%, 14.48 +/- 5.06% and 21.47 +/- 3.74% for HSV-1 (strain KOS); 5.96 +/- 2.51%, 8.75 +/- 3.08% and 17.75 +/- 5.19% for HSV-1 (strain ATCC/VR-733); 5.13 +/- 2.38 %, 8.18 +/- 1.11% and 8.51 +/- 1.94% for poliovirus type 2; 8.30 +/- 4.24%; 13.33 +/- 4.66% and 24.27 +/- 2.18% for simian rotavirus SA11, at 0.312, 0.625 and 1.250 mM, respectively, when measured by the MTT assay. |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 4 | 2% |
| Malaysia | 1 | <1% |
| Indonesia | 1 | <1% |
| South Africa | 1 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 183 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 34 | 18% |
| Student > Ph. D. Student | 30 | 16% |
| Researcher | 28 | 15% |
| Student > Master | 23 | 12% |
| Student > Postgraduate | 13 | 7% |
| Other | 28 | 15% |
| Unknown | 37 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 29% |
| Biochemistry, Genetics and Molecular Biology | 33 | 17% |
| Chemistry | 13 | 7% |
| Immunology and Microbiology | 12 | 6% |
| Medicine and Dentistry | 10 | 5% |
| Other | 23 | 12% |
| Unknown | 46 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#2,650,203
of 25,374,917 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#54
of 1,502 outputs
Outputs of similar age
#3,533
of 56,713 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#1
of 1 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,713 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them