OBJECTIVE To evaluate the efficacy of Calendula officinalis in relation to Essential Fatty Acids for the prevention and treatment of radiodermatitis. METHOD This is a randomized double-blind controlled clinical trial with 51 patients with head and neck cancer in radiotherapy treatment divided into two groups: control (27) and experimental (24). RESULTS There is statistically significant evidence (p-value = 0.0120) that the proportion of radiodermatitis grade 2 in Essential Fatty Acids group is higher than Calendula group. Through the Kaplan-Meier survival curve we observed that Essential Fatty Acids group has always remained below the Calendula group survival curve, due to the lower risk of developing radiodermatitis grade 1, which makes the usage of Calendula more effective, with statistical significance (p-value = 0.00402). CONCLUSION Calendula showed better therapeutic response than the Essential Fatty Acids in the prevention and treatment of radiodermatitis. Brazilian Registry of Clinical Trials: RBR-237v4b.
Pharmacology, Toxicology and Pharmaceutical Science
11
11%
Agricultural and Biological Sciences
6
6%
Veterinary Science and Veterinary Medicine
2
2%
Other
13
13%
Unknown
38
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2015.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Revista da Escola de Enfermagem da USP
#566
of 771 outputs
Outputs of similar age
#207,728
of 279,166 outputs
Outputs of similar age from Revista da Escola de Enfermagem da USP
#5
of 6 outputs
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So far Altmetric has tracked 771 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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