Title |
Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial*
|
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Published in |
Revista da Escola de Enfermagem da USP, April 2015
|
DOI | 10.1590/s0080-623420150000200006 |
Pubmed ID | |
Authors |
Franciane Schneider, Mitzy Tannia Reichembach Danski, Stela Adami Vayego |
Abstract |
OBJECTIVE To evaluate the efficacy of Calendula officinalis in relation to Essential Fatty Acids for the prevention and treatment of radiodermatitis. METHOD This is a randomized double-blind controlled clinical trial with 51 patients with head and neck cancer in radiotherapy treatment divided into two groups: control (27) and experimental (24). RESULTS There is statistically significant evidence (p-value = 0.0120) that the proportion of radiodermatitis grade 2 in Essential Fatty Acids group is higher than Calendula group. Through the Kaplan-Meier survival curve we observed that Essential Fatty Acids group has always remained below the Calendula group survival curve, due to the lower risk of developing radiodermatitis grade 1, which makes the usage of Calendula more effective, with statistical significance (p-value = 0.00402). CONCLUSION Calendula showed better therapeutic response than the Essential Fatty Acids in the prevention and treatment of radiodermatitis. Brazilian Registry of Clinical Trials: RBR-237v4b. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 1% |
Unknown | 95 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 16 | 17% |
Student > Master | 13 | 14% |
Other | 10 | 10% |
Student > Doctoral Student | 9 | 9% |
Researcher | 9 | 9% |
Other | 13 | 14% |
Unknown | 26 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 20% |
Nursing and Health Professions | 13 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 11% |
Agricultural and Biological Sciences | 6 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 14 | 15% |
Unknown | 31 | 32% |