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Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, September 2011
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Title
Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants
Published in
Brazilian Journal of Medical and Biological Research, September 2011
DOI 10.1590/s0100-879x2011007500112
Pubmed ID
Authors

T. Fernandes, U.P.R. Soci, E.M. Oliveira

Abstract

Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway involved, also showing that the cardiac markers of pathological hypertrophy (atrial natriuretic factor, β-myosin heavy chain and α-skeletal actin) are not increased. There is no fibrosis and no cardiac dysfunction in eccentric or concentric hypertrophy induced by exercise training. Therefore, the renin-angiotensin system has been implicated as one of the regulatory mechanisms for the control of cardiac function and structure. Here, we show that the angiotensin II type 1 (AT1) receptor is locally activated in pathological and physiological cardiac hypertrophy, although with exercise training it can be stimulated independently of the involvement of angiotensin II. Recently, microRNAs (miRs) have been investigated as a possible therapeutic approach since they regulate the translation of the target mRNAs involved in cardiac hypertrophy; however, miRs in relation to physiological hypertrophy have not been extensively investigated. We summarize here profiling studies that have examined miRs in pathological and physiological cardiac hypertrophy. An understanding of physiological cardiac remodeling may provide a strategy to improve ventricular function in cardiac dysfunction.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 2%
Spain 1 <1%
Unknown 185 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 16%
Student > Master 30 16%
Student > Bachelor 25 13%
Researcher 18 10%
Student > Postgraduate 18 10%
Other 31 16%
Unknown 36 19%
Readers by discipline Count As %
Medicine and Dentistry 43 23%
Agricultural and Biological Sciences 30 16%
Sports and Recreations 22 12%
Biochemistry, Genetics and Molecular Biology 19 10%
Nursing and Health Professions 9 5%
Other 21 11%
Unknown 45 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2011.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#901
of 1,254 outputs
Outputs of similar age
#112,836
of 135,970 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#10
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,254 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.