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Mendeley readers
| Title |
Comparative histological study on wound healing on rat's skin treated with Mitomycin C or Clobetasol propionate
|
|---|---|
| Published in |
Acta Cirurgica Brasileira, September 2015
|
| DOI | 10.1590/s0102-865020150090000002 |
| Pubmed ID | |
| Authors |
Maria de Fátima Pereira de Carvalho, Celina Siqueira Barbosa Pereira, José Humberto Fregnani, Fernando de Andrade Quintanilha Ribeiro |
| Abstract |
To compare histologically the action of Mitomycin C and that of Clobetasol propionate for surgical wound healing in rats. A circular skin fragment was surgically removed from 57 Wistar rats. Twenty-two animals were treated with Mitomycin C with topical medication in a single dose, 22 with Clobetasol propionate with a cream medication once a day for 15 days and 13 did not receive any medication. The animals were euthanized 30 and 60 days, and the scars subjected to histological examination. The histological analysis on the samples did not show statistically significant differences regarding the quantities of fibroblasts, fibrocytes and vascular proliferation in the three groups, in the evaluations after 30 and 60 days. In the treated groups with Mitomycin C and Clobetasol there was a decrease in collagen concentration over the 30-day period and an increase in collagen concentration over the 60-day period, in comparison with the control group. The actions of Mitomycin C and Clobetasol were equivalent and not interfere in fibroplasias and in angiogenesis. Both drugs initially cause a decrease in collagen over a 30-day period and an increase over a 60-day period, demonstrating a delay in the wound healing. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 17% |
| Student > Doctoral Student | 3 | 13% |
| Researcher | 2 | 9% |
| Student > Master | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Other | 3 | 13% |
| Unknown | 7 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Veterinary Science and Veterinary Medicine | 2 | 9% |
| Agricultural and Biological Sciences | 2 | 9% |
| Unspecified | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 8 | 35% |