Title |
Effect of ozone on colon anastomoses in rat peritonitis model1
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Published in |
Acta Cirúrgica Brasileira, February 2016
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DOI | 10.1590/s0102-865020160020000005 |
Pubmed ID | |
Authors |
Tuğrul Çakır, Arif Aslaner, Seçkin Özgür Tekeli, Sema Avcı, Uğur Doğan, Feyza Tekeli, Hakan Soylu, Cebrail Akyüz, Süleyman Koç, İsmail Üstünel, Necat Yılmaz |
Abstract |
To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-α and IL-1β, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels. Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1β and the VEGF immunostaining densities were also compared. Intraperitoneal ozone administration reversed TNF-α, IL-1β, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
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Student > Bachelor | 4 | 16% |
Researcher | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Other | 8 | 32% |
Unknown | 5 | 20% |
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Medicine and Dentistry | 7 | 28% |
Veterinary Science and Veterinary Medicine | 4 | 16% |
Agricultural and Biological Sciences | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Unspecified | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 32% |