Title |
Necessidades proteicas, morbidade e mortalidade no paciente grave: fundamentos e atualidades
|
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Published in |
Revista Brasileira de Terapia Intensiva, March 2013
|
DOI | 10.1590/s0103-507x2013000100010 |
Pubmed ID | |
Authors |
Haroldo Falcão Ramos da Cunha, Eduardo Eiras Moreira da Rocha, Monica Hissa |
Abstract |
Recent evidence suggests that a negative protein balance secondary to severe disease is associated with increased morbidity. A loss of total body protein is inevitable in this scenario, even with an aggressive nutritional approach, primarily due to the catabolism of skeletal muscle fibers. The ubiquitin-proteasome system is the primary metabolic and biochemical mechanism involved in this process; paradoxically, this system consumes adenosine triphosphate as its energy source. It is possible that a neutral protein balance in these clinical situations is important for improving outcomes and achieving the caloric goals estimated or measured by indirect calorimetry. Recent studies have suggested that the use of higher protein concentrations in nutritional therapy for critically ill patients may help to reduce mortality. The purpose of this study was to review some of the nutrition therapy principles related to protein metabolism, evaluate the main assertions of the guidelines of specialty societies and review the recent studies that address these issues using critical insights from the authors' clinical experience. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 19% |
Student > Bachelor | 9 | 16% |
Student > Doctoral Student | 7 | 12% |
Researcher | 5 | 9% |
Student > Ph. D. Student | 5 | 9% |
Other | 10 | 17% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 47% |
Nursing and Health Professions | 12 | 21% |
Agricultural and Biological Sciences | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 3 | 5% |
Unknown | 12 | 21% |