Title |
High prevalence of hepatitis C associated with familial history of hepatitis in a small town of south Brazil: efficiency of the rapid test for epidemiological survey
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Published in |
Brazilian Journal of Infectious Diseases, October 2010
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DOI | 10.1590/s1413-86702010000500010 |
Pubmed ID | |
Authors |
Cláudia Alexandra Pontes Ivantes, Danilo Silva, Iara Messias-Reason |
Abstract |
This report describes a cross-sectional survey on the prevalence of hepatitis C antibodies (anti-HCV) in Tamboara, a small community in the northwest area from Paraná State, south of Brazil with a high rate of accumulated detection for HCV. Eight hundred and sixteen residents (17.87% from all the population), independently of the age and time living in Tamboara were included in this study by an epidemiologic questionnaire and by testing for anti-HCV. The rapid immuno-chromatographic test was applied for detection of HCV antibodies. The anti-HCV prevalence by rapid test was 4.28%. The median age for positive and negative test was 60.49 ± 14.14 and 41.67 ± 20.25, respectively (p < 0.001). By multivariate analysis, only familial history of hepatitis (p = 0.001; OR = 6.41; CI 95% = 2.08-19.78) and age (p = 0.007; OR 1.06;95% CI = 1.02-1.10) showed statistical significance for positive anti-HCV. The rapid test sensitivity and specificity were 100% and 92.7% respectively, with an accuracy of 95.8% (95% CI = 91-100). These findings demonstrated a high prevalence of anti-HCV in Tamboara. The familial history of hepatitis was a significant risk factor to the infection and HCV rapid test showed to be accurate and feasible for epidemiological survey. |
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Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 5 | 19% |
Professor > Associate Professor | 4 | 15% |
Student > Bachelor | 3 | 12% |
Student > Master | 3 | 12% |
Other | 2 | 8% |
Other | 7 | 27% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 5 | 19% |
Nursing and Health Professions | 3 | 12% |
Social Sciences | 3 | 12% |
Economics, Econometrics and Finance | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 19% |