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CYP1A1 genotypes and haplotypes and risk of oral cancer: a case-control study in South Indians

Overview of attention for article published in Genetics and Molecular Biology, May 2012
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Title
CYP1A1 genotypes and haplotypes and risk of oral cancer: a case-control study in South Indians
Published in
Genetics and Molecular Biology, May 2012
DOI 10.1590/s1415-47572012005000024
Pubmed ID
Authors

Lakshmi Balaji, Krishna Balaji Singh, Lakkakula V.K.S. Bhaskar

Abstract

The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Researcher 5 21%
Student > Master 3 13%
Student > Doctoral Student 2 8%
Student > Bachelor 2 8%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 9 38%
Agricultural and Biological Sciences 8 33%
Biochemistry, Genetics and Molecular Biology 1 4%
Environmental Science 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 1 4%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2012.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Genetics and Molecular Biology
#551
of 771 outputs
Outputs of similar age
#137,854
of 176,129 outputs
Outputs of similar age from Genetics and Molecular Biology
#3
of 12 outputs
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So far Altmetric has tracked 771 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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