Title |
Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans
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Published in |
Genetics and Molecular Biology, July 2012
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DOI | 10.1590/s1415-47572012005000048 |
Pubmed ID | |
Authors |
Valeria Peralta-Leal, Evelia Leal-Ugarte, Juan P. Meza-Espinoza, Ingrid P. Dávalos-Rodríguez, Anabel Bocanegra-Alonso, Rosa I. Acosta-González, Enrique Gonzales, Saraswathy Nair, Jorge Durán-González |
Abstract |
The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 21% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Researcher | 3 | 9% |
Professor > Associate Professor | 2 | 6% |
Other | 3 | 9% |
Unknown | 13 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Psychology | 3 | 9% |
Unspecified | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 4 | 12% |
Unknown | 15 | 44% |