You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
|
|---|---|
| Published in |
Sao Paulo Medical Journal, April 1997
|
| DOI | 10.1590/s1516-31801997000200004 |
| Pubmed ID | |
| Authors |
Carlos ltio Tanaka, Luiz Henrique Gebrim, Geraldo Rodrigues de Lima, Manuel de Jesus Simões |
| Abstract |
Tamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transformation has not been fully elucidated. This prospective, randomized study assessed the estrogen activity of tamoxifen on the mammary gland epithelium of premenopausal patients using a quantitative analysis of mammary epithelium lysosome identified by the cytochemical technique of GOMORI for acid phosphatase and by light microscopy. Tamoxifen significantly increased the number of lysosomes only during the secretory phase of the menstrual cycle. We concluded that the early effect of the drug on normal mammary tissue is synergistic with the effect of estrogen during the premenopausal period. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 8% |
| Unknown | 12 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 31% |
| Lecturer | 1 | 8% |
| Student > Ph. D. Student | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Student > Master | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 4 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 2 | 15% |
| Medicine and Dentistry | 2 | 15% |
| Psychology | 2 | 15% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Sports and Recreations | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 4 | 31% |