Title |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
|
---|---|
Published in |
International Brazilian Journal of Urology, July 2011
|
DOI | 10.1590/s1677-55382011000300002 |
Pubmed ID | |
Authors |
Alexandros Drivalos, Athanasios G. Papatsoris, Michael Chrisofos, Eleni Efstathiou, Meletios A. Dimopoulos |
Abstract |
During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Slovakia | 1 | 4% |
South Africa | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 31% |
Researcher | 4 | 15% |
Student > Ph. D. Student | 3 | 12% |
Student > Bachelor | 2 | 8% |
Professor | 1 | 4% |
Other | 3 | 12% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 42% |
Agricultural and Biological Sciences | 5 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Immunology and Microbiology | 1 | 4% |
Computer Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 5 | 19% |