Title |
Chronic intermittent hypoxia increases encoding pigment epithelium-derived factor gene expression, although not that of the protein itself, in the temporal cortex of rats*,**
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Published in |
Jornal de Pneumologia, January 2015
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DOI | 10.1590/s1806-37132015000100006 |
Pubmed ID | |
Authors |
Guilherme Silva Julian, Renato Watanabe de Oliveira, Vanessa Manchim Favaro, Maria Gabriela Menezes de Oliveira, Juliana Cini Perry, Sergio Tufik, Jair Ribeiro Chagas |
Abstract |
Obstructive sleep apnea syndrome is mainly characterized by intermittent hypoxia (IH) during sleep, being associated with several complications. Exposure to IH is the most widely used animal model of sleep apnea, short-term IH exposure resulting in cognitive and neuronal impairment. Pigment epithelium-derived factor (PEDF) is a hypoxia-sensitive factor acting as a neurotrophic, neuroprotective, and antiangiogenic agent. Our study analyzed performance on learning and cognitive tasks, as well as PEDF gene expression and PEDF protein expression in specific brain structures, in rats exposed to long-term IH. |
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