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Influência de contraceptivos hormonais sobre indicadores de homeostase de zinco e de turnover ósseo em mulheres adultas jovens

Overview of attention for article published in Revista brasileira de ginecologia e obstetrícia revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, September 2015
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Title
Influência de contraceptivos hormonais sobre indicadores de homeostase de zinco e de turnover ósseo em mulheres adultas jovens
Published in
Revista brasileira de ginecologia e obstetrícia revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, September 2015
DOI 10.1590/so100-720320150005418
Pubmed ID
Authors

Tania Mara Rodrigues Simões, Carmiña Lucía Vargas Zapata, Carmen Marino Donangelo

Abstract

To investigate the influence of the use of oral hormonal contraceptive agents (OCA) on the biochemical indices related to metabolic zinc utilization and distribution, and to bone turnover in young adult women. Cross-sectional study. Blood and urine samples from non-users (-OCA; control; n=69) and users of hormonal contraceptives for at least 3 months (+OCA; n=62) were collected under controlled conditions. Indices of zinc homeostasis and of bone turnover were analyzed in serum or plasma (total, albumin-bound and α2-macroglobulin-bound zinc, albumin and total and bone alkaline phosphatase activity), in erythrocytes (zinc and metallothionein) and in urine (zinc, calcium and hydroxyproline). The habitual zinc and calcium intakes were evaluated by a food frequency questionnaire. Dietary zinc intake was similar in both groups and on average above recommended values, whereas calcium intake was similarly sub-adequate in +OCA and -OCA. Compared to controls, +OCA had lower concentrations of total and α2-macroglobulin-bound zinc (11 and 28.5%, respectively, p<0.001), serum albumin (13%, p<0.01), total and bone-specific alkaline phosphatase activity (13 and 18%, respectively, p<0.05), erythrocyte metallothionein (13%, p<0.01), and, urinary zinc (34%, p<0.05). OCA use decreases serum zinc, alters zinc distribution in major serum fractions with possible effects on tissue uptake, enhances zinc retention in the body and decreases bone turnover. Prolonged OCA use may lead to lower peak bone mass and/or to impaired bone mass maintenance in young women, particularly in those with marginal calcium intake. The observed OCA effects were more evident in women younger than 25 years and in nulliparous women, deserving special attention in future studies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer 1 33%
Student > Postgraduate 1 33%
Unknown 1 33%
Readers by discipline Count As %
Sports and Recreations 1 33%
Medicine and Dentistry 1 33%
Unknown 1 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2017.
All research outputs
#23,320,957
of 25,986,827 outputs
Outputs from Revista brasileira de ginecologia e obstetrícia revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
#2
of 2 outputs
Outputs of similar age
#239,007
of 278,010 outputs
Outputs of similar age from Revista brasileira de ginecologia e obstetrícia revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
#5
of 5 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2 research outputs from this source. They receive a mean Attention Score of 0.9. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,010 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.