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Effects of isotretinoin on the olfactory function in patients with acne

Overview of attention for article published in Anais Brasileiros de Dermatologia, March 2017
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Title
Effects of isotretinoin on the olfactory function in patients with acne
Published in
Anais Brasileiros de Dermatologia, March 2017
DOI 10.1590/abd1806-4841.20175483
Pubmed ID
Authors

Demet Kartal, Mehmet Yaşar, Levent Kartal, Ibrahim Özcan, Murat Borlu

Abstract

Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice. This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy. Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination. Olfactory function was assessed by the Sniffin' Sticks Test. The test was assessed at baseline and in the third month of isotretinoin treatment. Isotretinoin improved the performance of patients in the olfactory test. The SST score increased from 8.7±1.09 to 9.5±1.19 (p<0.001), prevalence of hyposmia decreased from 40% to 24% and normosmia increased from 60% to 75% (p=0.059). The percentage of patients whose olfactory function was categorized as "good" increased from 6% to 21.3%. This increase was statistically significant (p<0.05). Absence of a control group is one of the limitations of this study. Also, we did not evaluate patients with smell test after stopping isotretinoin treatment. We examined the effect of systemic isotretinoin on olfactory function. It can be concluded from the present investigation that isotretinoin therapy improves the sense of smell.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 18%
Student > Bachelor 5 18%
Student > Master 3 11%
Professor 1 4%
Professor > Associate Professor 1 4%
Other 1 4%
Unknown 12 43%
Readers by discipline Count As %
Medicine and Dentistry 9 32%
Arts and Humanities 1 4%
Chemical Engineering 1 4%
Psychology 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 7%
Unknown 13 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2017.
All research outputs
#21,158,537
of 25,988,468 outputs
Outputs from Anais Brasileiros de Dermatologia
#405
of 575 outputs
Outputs of similar age
#255,037
of 327,827 outputs
Outputs of similar age from Anais Brasileiros de Dermatologia
#1
of 1 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 575 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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