Title |
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: clinicopathological features and long-term outcomes following a pancreatectomy.
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Published in |
Revista Española de Enfermedades Digestivas, January 2018
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DOI | 10.17235/reed.2018.5646/2018 |
Pubmed ID | |
Authors |
Javier Antoñanzas, Javier A Cienfuegos, Luis Hurtado-Pardo, Pablo Panadero, Alberto Benito, Fernando Pardo, Fernando Rotellar, Pablo Martí-Cruchaga, Gabriel Zozaya, Víctor Valentí, José Luis Hernández Lizoain |
Abstract |
the objective of this study was to analyze the anatomical and clinical features and long-term oncologic outcomes of 25 patients that underwent surgery due to intraductal papillary mucinous neoplasm of the pancreas. patients undergoing surgery for intraductal papillary mucinous neoplasm of the pancreas were identified from a prospective database of pancreatic resections. Demographic data, symptoms, type of surgery and type of lesion (branch type, main duct or mixed) were recorded. The lesions were classified into invasive (high grade dysplasia and carcinoma) and noninvasive (low- or intermediate-grade dysplasia). Postoperative complications were analyzed as well as the pattern of recurrence and disease-free survival at five and ten years. the most common symptoms in the 25 patients (14 males and eleven females) were abdominal pain and weight loss. Eight (32%) cases were diagnosed incidentally. Twelve (48%) of the lesions were of the branch type, three affected the main duct and ten (40%) were mixed. Twelve cephalic duodenopancreatectomies and seven total pancreatectomies were performed; three were central; two, distal; and one, enucleation. Seven cases (32%) had an invasive phenotype. Three patients had locoregional and distant recurrence at six, 16 and 46 months after surgery with a median follow-up of 7.7 years. Disease-free survival at five and ten years for the noninvasive type was 94% and 57% for invasive phenotypes (p < 0.05). intraductal papillary mucinous neoplasm is a heterogeneous entity with well differentiated phenotypes, which requires a tailored strategy and treatment, as established in the current consensus guidelines due to its malignant potential. |
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Mexico | 1 | 50% |
Unknown | 1 | 50% |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Librarian | 3 | 14% |
Researcher | 3 | 14% |
Other | 2 | 9% |
Student > Bachelor | 2 | 9% |
Student > Master | 2 | 9% |
Other | 3 | 14% |
Unknown | 7 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Agricultural and Biological Sciences | 1 | 5% |
Unknown | 11 | 50% |